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CXCR4 signaling determines the fate of hematopoietic multipotent progenitors by stimulating mTOR activity and mitochondrial metabolism. Rondeau V, Kalogeraki M, Roland L, Nader ZA, Gourhand V, Bonaud A, Lemos J, Khamyath M, Moulin C, Schell B, Delord M, Bidaut G, Lecourt S, Freitas C, Anginot A, Mazure N, McDermott DH, Parietti V, Setterblad N, Dulphy N, Bachelerie F, Aurrand-Lions M, Stockholm D, Lobry C, Murphy PM, Espéli M, Mancini SJC, Balabanian K. Sci Signal. 2024 Oct 29;17(860):eadl5100. doi: 10.1126/scisignal.adl5100. Epub 2024 Oct 29. PMID: 39471249

PNAS -- Sec22b is a critical and nonredundant regulator of plasma cell maintenance

Nature Com -- WHIM Syndrome-linked CXCR4 mutations drive osteoporosis

Plasma cells are mini-factories responsible for antibody production and secretion..