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_{Karl
BALABANIAN}

Karl BALABANIAN

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Karl Balabanian is Director of Research at INSERM and leads the research team “Chemokines, lymphoid niches and Immunopathology” at Saint-Louis Hospital in the U1160 INSERM unit associating both the INSERM and University Paris Cité. He is an Immunologist specialized for more than 20 years in the genetic, molecular and functional aspects of the interactions established between chemokines and their receptors on lymphoid progenitors and mature lymphocytes as well as on their environment at steady state and in the course of human immuno-hematological disorders. By using bedside-to-bench approaches combining molecular and functional investigation son human samples and pre-clinical mouse models and thanks to long-standing collaborations with academic and clinical department in France and abroad, he made seminal breakthroughs in the field including the discovery of ACKR3/CXCR7as the second receptor of CXCL12 and the identification, molecular characterization and modeling of CXCR4 dysfunctions in rare immunodeficiencies, and notably the WHIM Syndrome. Karl Balabanian is the co-author of >80 peer reviewed articles and 4 patent applications.

Marion ESPÉLI

Marion Espéli is an Inserm scientist (Chargée de Recherche) and co-directs with Karl Balabanian the research team “Chemokines, lymphoid niches and Immunopathology” at Saint-Louis Hospital inthe U1160 INSERM unit associating both the INSERM and University Paris Cité.For the last 20 years she has been working on the mechanisms controlling B cell differentiation and activation under normal and pathological conditions. Since coming back to France in 2014, she develops an integrative analysis of plasmacell biology covering their differentiation, survival, and migratory behavior, their function as antibody-secreting cells as well as their heterogeneity at the single cell level. Marion Espéli is the co-author of > 50 peer reviewed articles and since 2022, she is chair and spokesperson of the European B cell Network (EBCNet) study group.

_{Marion
ESPÉLI}

_{Nicolas DULPHY}

Nicolas DULPHY

Nicolas Dulphy is an immunologist. He is developing projects aimed at studying Natural Killer and Innate lymphoid cell populations and their relationship with the marrow microenvironment (in particular mesenchymal stromal cells) during haematological malignancies (myelodysplastic syndromes and acute myeloid leukaemia).

Hélène MOINS

Hélène Moins is a MD Ph-D, professor of Immunology at UP Cité. Her research is focused on cutaneous T cell lymphomas, in close collaboration with the Dermatology department at Saint-Louis Hospital. She aims to analyze the complexity of these diseases, characterized by a continuous interplay between blood and skin, involving both malignant and non-malignant cells of the immune system and distinctcytokine / chemokine environments. She has founded theCyTHem Sézary group (national network for standardized flow cytometry in CTCL)and is also involved in international clinical trials as an expert consultant. She coordinates and teaches immunology at the faculty of Medicine.

_{Hélène
MOINS}

_{Van Anh
TA}

Van Anh TA

Van Anh Ta is a PhD student. His present research focuses on immunotherapy and the exploration of novel diagnostic techniques as a potential therapeutic approach for Sezary syndrome. This rare and aggressive type of T-cell cutaneous lymphoma affects both the skin and blood "

Elisabeth COHEN

Elisabeth Cohen She is a medical resident specializing in dermatology. Currently, she is pursuing amaster's degree in immunology. His project aims to characterize the immune restoration of patients with Sezary syndrome, a lymphoma affecting blood and skin.

_{Elisabeth
COHEN}

_{Emilie LERECLUS}

Emilie LERECLUS

Emilie Lereclus is a PhD working in AP-HP and currently Research Project Manager of the FHU PROTHEE and Research Engineer in the lab supervised by Karl Balabanian.
She is interested in immune cells populations and microenvironment of prosthetic joint infections
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Vanessa GOURHAND

Vanessa Gourhand is a tenured INSERM assistant Engineer investigating how CXCR4 signaling regulates the metabolic and epigenetic fate of hematopoietic multipotent progenitors.

_{Vanessa GOURHAND}

_{Valeria
BISIO}

Valeria BISIO

Valeria Bisio is a Post-doctoral Fellow (PhD) in the lab supervised by Nicolas Dulphy. She got a Ph.D. in Onco-hematology at the University of Padua (Italy) and focused her work on the characterization of new markers for better stratifying children with leukemia. Today her works concern the study of Bone Marrow Immunology in Myelodysplastic Syndrome.ttps://orcid.org/0000-0002-5459-2123

Mélanie KHAMYATH

Mélanie KHAMYATH is a third-year PhD Student at Institut de Recherche Saint-Louis in Paris.She graduated from Université Paris Cité with a Bachelor in biology and a Master in immunology and immunopathology. Her thesis project focuses on a new mice model carrying double mutations of CXCR4 and MyD88 which reproduce Waldenström macroglobulinemia disease. This model will pave the way to interrogate the pathological mechanisms at the basis of the disease.

_{Mélanie KHAMYATH}

_{Lin-Pierre ZHAO}

Lin-Pierre ZHAO

Lin-Pierre is a physician working in Saint-Louis Hospital and currently PhD candidate in the lab. He is particularly interested in lymphopoiesis, and in the immunological defects associated with clonal hematopoiesis and myeloid malignancies.
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Zeina ABOU NADER

Zeina ABOU NADER is a 4th year PhD student in our lab. She works on the role of CXCR4/CXCL12 signaling in the interaction between Lymphoid Progenitors and Mesenchymal Stromal Cells in the bone marrow using the mouse model carrying the gain-of-function mutation of CXCR4.

_{Zeina
ABOU NADER}

_{Pierre-Edouard
DEBUREAUX}

Pierre-Edouard DEBUREAUX

Pierre-Edouard Debureaux is a hematologist working in Saint-Louis Hospital and currently first year PhD student in Immunology in the lab. His PhD thesis is about role of inflammation in Waldenström macroglobulinemia and is supervised by Karl Balabanin and Marion Espeli. He is particularly interested in immunology and Waldenström macroglobulinemia. He got a 3-year grant from ITMO cancer/AVISAN for his PhD.

Maria KALOGERAKI

Maria is a PhD investigating how CXCR4 signaling regulates the metabolic and epigenetic fate of hematopoietic multipotent progenitors.
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_{Maria KALOGERAKI}

_{Clémentine MOULIN}

Clémentine MOULIN

Clémentine Moulin is a medical biologist, PharmD, particularly interested in the defects in cellular immunity observed in immunocompromised patients. She is currently a PhD student in the lab supervised by Marion Espeli and Karl Balabanian, working on the role of the inflammaging in the responses to infections and vaccines in WHIM Syndrome patients.

Houda MELHEM

Houda Melhem is a M2 student specializing in Systems and Integrative Immunology under the supervision of Dr Marion ESPELI. During her internship sheis particularly interested in the impact of CXCR4 mutation on the transcriptome and metabolism of B cells populations.

_{Melhem HOUDA}

_{Inès
M’SIBIH}

Inès M’SIBIH

Inès M’SIBIH is studying Oncology in Gustave Roussy Institute and currently M2 student in the lab supervised by Nicolas Dulphy. She is interested in the field of microenvironment in clonal hematopoiesis and myeloid malignancies.